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Best sinus medicines - July 2025

Last Updated - July 22, 2025

1
Best Choice
21% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex
21% Off

Mucinex Sinus-Max Day Pressure, Pain & Cough & Nightshift Night Sinus Medicine for Adults, Day/Night Combo Pack for Sore Throat Relief, Nasal Congestion Relief, Cough & Cold Medicines, 40 Caplets

Mucinex

$17.75

$22.49
(21% Off)

More Details
Main highlights
- USAGE: Use as directed; For ages 12+ years
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended OTC Expectorant**; Get the brand that doctors trust and recommend
- SORE THROAT RELIEF: Both products contain Acetaminophen, which helps relieve sore throat, headache, and body pain
- SINUS MEDICINE FOR ADULTS: This combo pack of Maximum Strength Mucinex Sinus-Max Day Pressure, Pain & Cough and Nightshift Night Sinus fast-release caplets provides powerful multi-symptom relief for your worst cough, cold, and sinus symptoms
- NIGHTTIME COLD AND FLU MEDICINE FOR ADULTS: Nighttime caplets contain Triprolidine HCl, an antihistamine, which helps relieve runny nose & sneezing
- NASAL DECONGESTANT: Both products contain Phenylephrine HCl, a nasal decongestant, which helps relieve stuffy nose, sinus pressure, & nasal congestion
- FSA/HSA STORE ELIGIBLE MEDICATION: Save Up to 30%; Cover out-of-pocket expenses with pre-tax dollars (Product eligibility may vary by plan; Check with your benefits administrator to determine which expenses are eligible before you shop)
- COUGH MEDICINE FOR ADULTS: Both products contain Dextromethorphan HBr, which helps suppress and quiet cough
- CHEST CONGESTION RELIEF: Daytime cold medicine caplets contain Guaifenesin, an expectorant, which helps relieve chest congestion and thins and loosens mucus
- *IQVIA using ProVoice Survey, August 2023; **U.S. News & World Report/Pharmacy Times 2023-2024
$17.75
$22.49 (21% Off)
2
16% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

GenCare
16% Off

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

GenCare

$14.99

$17.99
(16% Off)

More Details
Main highlights
- ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
- NON DROWSY FORMULA - GenCare Nasal Decongestion can be taken any time of day including the morning or daytime. Many decongestant treatments are only suitable for nighttime use and are therefore limited for active adults and kids who need relief all day long.
- BULK SAVINGS BOTTLE - Stop worrying about constant refills with our value savings 300 tablet family size bottle. This is the perfect size for families or people who suffer from chronic congestion due to allergies or seasonal illness.
- BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
- 100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 300 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of nasal decongestion customers...Click Add-to-Cart Today
$14.99
$17.99 (16% Off)
3
Best Value
19% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed
19% Off

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Sudafed

$8.54

$10.67
(19% Off)

More Details
Main highlights
- PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
- NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
- FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
$8.54
$10.67 (19% Off)
4
16% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Boiron
16% Off

Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

Boiron

$9.14

$10.99
(16% Off)

More Details
Main highlights
- The non-drowsy, quick-dissolving tablets are phenylephrine-free and won’t interact with other medications. Free from preservatives and artificial colors & flavors.
- Tablets dissolve quickly under the tongue without water, chewing, or swallowing pills.
- SinusCalm tablets relieves nasal congestion, sinus pain and pressure, and headache due to the common cold or allergies.
- Non-habit forming and no risk of a rebound effect
- Available over the counter in a box of two multidose tubes for home or on the go (approximately 80 oral pellets per tube)
$9.14
$10.99 (16% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

Sudafed

$9.99

$10.67
(6% Off)

More Details
Main highlights
- From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief
- Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
- Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
- Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
- 20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
$9.99
$10.67 (6% Off)

Best sinus medicines - July 2025

Mucinex Sinus-Max Day Pressure, Pain & Cough & Nightshift Night Sinus Medicine for Adults, Day/Night Combo Pack for Sore Throat Relief, Nasal Congestion Relief, Cough & Cold Medicines, 40 Caplets

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

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HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Maximum Strength | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count (Pack of 1))

Vicks Sinex SEVERE Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Nasal Congestion due to Cold or Allergy, Sinus Pressure Relief, 265 Sprays x 2

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy and Cough Medicine for Adults and Children 12 Years and Older - Relieves Symptoms from Allergies, Colds or Hay Fever, 24 Count

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